What is known?
- Hirschsprung’s disease is the migration deficiency of neural crest
cells during the development of the bowels in the fetal period.
- Disgnosis of Hirschsprung’s disease is made by demonstrating the
complete absence of enteric ganglion cells in the submucosal and
myenteric plexuses of the distal colon with rectal aspiration biopsy.
- Procedures such as anal dilatation or rectal irrigation used in the
diagnosis and treatment of Hirschsprung’s disease might contribute to
the insufficient biopsy.