Figure 1. The ECM, CAFs and Vasculature in TIME of EGFR mutant lung cancer.
A. The ECM in TIME of EGFR mutant lung cancer, EGFR mutant lung cancer cell overexpresses twist and snail, which induces EMT. EGFR mutant lung cancer cell also overexpresses MM9, which destructs the ECM barrier. EGFR-TKIs resistant lung cancer cell highly expresses integrin-β1. B. The CAFs in TIME of EGFR mutant lung cancer. In EGFR-TKIs sensitive lung cancer, the CAFs highly expresses CD200. In EGFR-TKIs resistant lung cancer, the CAFs highly expresses c-met and IGF-1, which induces tumor cell overexpresses ANX2 and EMT. The CAFs in TIME of EGFR-TKIs resistant lung cancer also expresses podoplanin. C. Vasculature in TIME of EGFR-TKIs resistant lung cancer. The expression of HGF promotes the activation of MET, which stimulates the production of VEGFR. The activation of c-MYC and overexpression of HIF-α also induces EGFR-TKIs resistance.