Tumor infiltrating immune cells
At present, the majority of research on tumor immune microenvironment is
tumor infiltrating immune cells, and almost All immune cell types can be
found in the tumor microenvironment, including tumor associated
macrophages (TAM), dendritic cells (DC), natural killer cells (NK), B
lymphocytes (B cell), T lymphocytes (T cell), marrow-derived suppressor
cells (MDSC), neutrophils, etc.[61]. The immune cells play an
important role in shaping the TIME of EGFR mutant lung cancer by
secreting cytokines and activating signal pathways (Figure 2).