Neutrophils
Neutrophils which are the largest number of immune cells in humans have
always been considered as uncomplicated front-line troopers of the
innate immune system. Recently, studies have found that neutrophils are
associated with anti-tumor immune response[79]. Several studies have
found that a low neutrophil-to-lymphocyte ratio was a good prognostic
factor in EGFR mutant NSCLC patients receiving EGFR-TKIs
treatment[80-82]. Another study found that intratumoral neutrophil
density was lower in EGFR mutant NSCLC comparing with non- EGFR mutant
NSCLC[83]. At present, there are few studies on the relationship
between neutrophils and EGFR-TKIs resistance mechanism. Whether
neutrophils are related to EGFR-TKIs resistance needs further study.