Keywords: Acute kidney injury(AKI), Coronary artery bypass grafting (CABG)
Introduction: The incidence of acute kidney injury after CABG is high. According to the definition of AKI, the incidence rate has been reported to range from 6.7% to 39% 1-3. AKI is associated with increased complications and mortality after CABG3-5, which further increases in the more severe stage of AKI; acute kidney injury after cardiac surgery is independently associated with increased short-term and long-term mortality4,6-9. AKI after cardiac surgery also increases intensive care unit (ICU) length of stay and resource utilization2,10.
The development of AKI involves a variety of mechanisms, including ischemic reperfusion injury, renal toxin release, haemolysis, oxidative stress and cytokine secretion, which can cause a systemic inflammatory response, endothelial damage and renal tubular cell damage1,11-13. Many previous studies have shown that older age, low ejection fraction, a previous history of kidney disease, and long-term cardiopulmonary bypass are important predictors of AKI development 6,14-16.
With the popularization of CABG operations, an increasing number of patients with cardiovascular complications receive CABG treatment. Due to postoperative complications, the results may be unfavourable. Especially for the elderly patients, due to the relatively poor basic renal function of elderly patients, adverse complications after CABG are more likely to occur 17. However, there are few studies on the risk factors for AKI after CABG in elderly patients, especially in the Asian population. Therefore, this study retrospectively analysed the risk factors for AKI in Chinese elderly patients after CABG and established a risk prediction model. Early detection of these risk factors and active intervention measures will help to reduce the occurrence of AKI after CABG and improve the prognosis of elderly patients.