Abstract
Background and aim of the study: Elderly patients are more
likely to have adverse complications after coronary artery bypass
grafting (CABG). There are few studies on the risk factors for acute
kidney injury (AKI) after surgery in elderly patients, especially in the
Asian population. This study retrospectively analysed the risk factors
for AKI in Chinese elderly patients after CABG and established a risk
prediction model to detect these risk factors early and take active
intervention measures.
Methods: A total of 432 patients were included in this study
from 2018 to 2019. AKI was defined according to the Kidney Disease
Improving Global Outcomes (KDIGO) criteria. The patients were divided
into an AKI group and a non-AKI group. Multivariate logistic regression
analysis was used to screen out the factors with p <
0.05.
Results: Out of 432 patients in the study, 119 (27.5%)
developed AKI. The estimated glomerular filtration rate (eGFR), ≥3
coronary anastomoses, preoperative intra-aortic balloon pump (IABP)
implantation and prolonged ventilation time were independent risk
factors for AKI. The area under the ROC curve was 0.702 (95% confidence
interval (CI) [0.643-0.761], p < 0.001).
Conclusions: The eGFR, ≥3 coronary anastomoses, preoperative
IABP implantation and prolonged ventilation time are independent risk
factors for AKI in elderly patients undergoing coronary artery bypass
grafting. Early discovery of these risk factors and the implementation
of appropriate intervention measures are useful to reduce the occurrence
of AKI after CABG and improve the prognosis of patients.