Keywords: Acute kidney injury(AKI), Coronary artery bypass
grafting (CABG)
Introduction: The incidence of acute kidney injury after CABG
is high. According to the definition of AKI, the incidence rate has been
reported to range from 6.7% to 39% 1-3. AKI is
associated with increased complications and mortality after CABG3-5, which further increases in the more severe stage
of AKI; acute kidney injury after cardiac surgery is independently
associated with increased short-term and long-term mortality4,6-9. AKI after cardiac surgery also increases
intensive care unit (ICU) length of stay and resource utilization2,10.
The development of AKI involves a variety of mechanisms, including
ischemic reperfusion injury, renal toxin release, haemolysis, oxidative
stress and cytokine secretion, which can cause a systemic inflammatory
response, endothelial damage and renal tubular cell damage1,11-13. Many previous studies have shown that older
age, low ejection fraction, a previous history of kidney disease, and
long-term cardiopulmonary bypass are important predictors of AKI
development 6,14-16.
With the popularization of CABG operations, an increasing number of
patients with cardiovascular complications receive CABG treatment. Due
to postoperative complications, the results may be unfavourable.
Especially for the elderly patients, due to the relatively poor basic
renal function of elderly patients, adverse complications after CABG are
more likely to occur 17. However, there are few
studies on the risk factors for AKI after CABG in elderly patients,
especially in the Asian population. Therefore, this study
retrospectively analysed the risk factors for AKI in Chinese elderly
patients after CABG and established a risk prediction model. Early
detection of these risk factors and active intervention measures will
help to reduce the occurrence of AKI after CABG and improve the
prognosis of elderly patients.