2.5 Race
Genomic race was assigned from the PharmacoScanTMassay; allele frequencies from 1000genome populations (EUR, AFR, AMR, EAS and SAS) were used as references. We selected 1054 ancestry informative markers on the array with allele frequencies that differed at least 5% between any two populations. A likelihood method based on reference frequencies was then used to infer the admixture of population for each patient.22 Patients were then classified into race groups using the following criteria: Whites had European ancestry > 90%, Blacks had African ancestry > 70%, Asians had eastern or south Asian ancestry > 90%, Hispanics had Native American ancestry greater than 10% and higher Native American ancestry than any other non-European ancestry.
3. Results
G6PD genotype results were obtained in 1391 patients. ObservedG6PD genotypes by race and sex are presented in Table 1. The median age was 8.3 years (range: 54 days to 38 years); 89% were patients treated on an oncology service, 10% were patients treated on a hematology service (primarily with a sickle cell disease diagnosis), and 1% were patients treated on an infectious disease service.