Fig 3: SAT in wound healing. Wound healing consists of several regenerative phases: (1) Bleeding and hemostasis lead to platelet aggregation and coagulation (2) Inflammatory cells, such as neutrophils, macrphages are recruited to the site of injury to clear debris and microbes. Fibroblast and macrophages support the migration of keratinocytes and adipocytes secret adipokines such interleukins, leptin and adiponectin. (3) Secretion of growth factors and cytokines from adipocytes promotes fibroblast proliferation, re-epithelialization and neovascularization. Administration of ASC-derived exosomes can promote angiogenesis and re-epithelization (4) Adipocytes de-differentiate to myofibroblasts, which contributed to wound repair by producing extracellular matrix (ECM) which serve as scaffold.