Reversibility	Treatment	Outcome	Duration	Dose	Route of administration	Gender	Age	Case
Some reversibility	IV Pulse steroid 500 mg IV Methylprednisolone for 5 days	Right optic neuritis and aseptic neuritis	One dose	500 mg	IV	Female	30 years old	Our Case
Yes	Cefotaxime 500 mg BID IV for one week	Aseptic meningitis	One week	400 mg BID	Oral	Male	49 years old	A.Viharika et al [3]
Yes	Stopping Metronidazole	Bilateral optic neuritis	8 months	400 mg BID	Oral	Female	67 years old	Nicole M McGrath et al [4]
No	Stopping Metronidazole	Bilateral optic neuritis and meylitis	1 week	1000 mg OD	Oral	Female	57 years old	Pai-Huei-Peng et al [5]
Yes	Stopping Metronidazole	Optic neuritis	Two years	NA	NA	Male	36 years old	Natalie Anwyll et al [6]
Yes	Stopping Metronidazole	Aseptic meningitis	One dose	250 mg	Oral	Female	20 years old	Audrey P et al [7]
Yes	Stopping Metronidazole	Optic neuropathy and cerebellar toxicity	For two years	500 mg TID	oral	Female	58 years old	Erin Nuro et al [8]
Yes	Stopping Metronidazole	Bilateral optic neuritis	Two weeks	NA	Oral	Female	6 years and 8 years old	Bouraoui R et al [9]
Yes	Stopping Metronidazole	Aseptic meningitis	One dose	400 mg	Oral	Male	42 years old	Sujoy Khan et a [10]
Some reversibility	Stopping Metronidazole	Optic neuritis	7-365 days	750-1000 mg daily	Oral	4 females and 3 males	7 patients from 26-53 years old	Putnam et al [11]
Yes	Stopping Metronidazole Starting coenzyme Q10	Optic neuropathy and cerebellar toxicity	Over 6 months	500 mg TID	Oral	Male	17 years old	Kim M Cecil et al [12]
Yes	Stopping Metronidazole	Optic neuropathy	2 years	1500 mg daily	Oral	Male	20 years old	De Bleecker et al [13]