Modification of asparaginase therapy
When asked about what scenarios would prompt them to modify therapy from pegaspargase to Erwinia asparaginase, pegaspargase levels below threshold on any occasion was chosen as a response 11.1% of the time. Grade 4 infusion reactions was chosen 30.6% of the time, while Grade 3 infusion reactions were chosen 29.6% of the time, Grade 2 infusion reactions 12.9% of the time and Grade 1 infusion reactions only 0.9% of the time [4]. Other reasons for modification of therapy from pegaspargase to Erwinia asparaginase were provided as pancreatitis and thrombosis.
Most respondents (47.1%) indicated modifying therapy from pegaspargase to Erwinia asparaginase in 10-25% of patients treated. 31.4% of respondents indicated modifying therapy in <10% of patients treated. Only 5.9% of respondents indicated modifying therapy in 20-50% of patients treated, while one respondent has never modified therapy and 7 (13.67%) were unsure.