Measurement of pegaspargase levels
All but 3 respondents reported using primarily pegasparaginase
intravenously at their centre. Out of the 3 that were unsure, 2
respondents were from Eastern Canadian centres, and one from a Western
Canadian centre.
Twenty respondents (39.2%) reported routinely measuring levels. These
respondents were mostly from Eastern and Atlantic Canada. The most
common reasons for not routinely measuring asparaginase levels was that
respondents were unsure how to use levels clinically (relative
frequency=25.5%), were unsure if this was required (relative
frequency=21.6%) or felt there was no centre/laboratory available to
send the samples for analysis (relative frequency=19.6%). Other reasons
included cost (relative frequency=11.8%) and overall lack of knowledge
regarding how and when to send levels (relative frequency=13.7% for
each).
At hospitals that measure asparaginase levels, levels are reviewed
primarily by clinicians (including subspecialty residents, nurse
practitioners and physicians) (relative frequency=45.1%), but also by
pharmacists (relative frequency=19.6%).
When asked regarding timing of levels, Day 6-7 was the most popular
selection with a relative frequency of 29.4%. Day 0 was selected with a
relative frequency of 9.8%, Day 2 with a relative frequency of 1.9%
and Day 14 with a relative frequency of 9.8% (see Table 2).