Effects of sevoflurane or propofol on CXCL12 and CXCR4 expressions
According to immunofluorescent staining, the intensity of C-X-C motif chemokine ligand 12 (CXCL12) was increased in the sevoflurane group but decreased in the propofol group (Fig 5A ). In similar, the fluorescent staining of C-X-C motif chemokine receptor 4 (CXCR4) was higher in the sevoflurane group than the control, and the intensity of the marker was lower in the propofol group than the control (Fig 5B ). These results showed the expressions of CXCL12 and CXCR4 were both increased by sevoflurane but decreased by propofol administration.