Fig 1. The cell viability, proliferation, migration, and invasion of ovarian cancer cells after sevoflurane or propofol administration.
Ovarian cancer (SKOV3) cells were administered with pure culture media (naïve control), 2.5% sevoflurane, or 4 μg/mL propofol. The cell viability of ovarian cancer cells was evaluated with cell counting kit-8 assay (A). The cell proliferation of ovarian cancer cells was evaluated by identifying Ki-67 positive cells (B and C). The migration of SKOV3 cells was evaluated by calculating gap closure with wound healing assay (D and E). The invasion was evaluated by identifying invasive cells with Transwell assay (F and G). The data was expressed as mean ± standard deviation and dots plot (n = 6). *p < 0.05, **p < 0.01, ****p < 0.0001 versus naïve control. Scale bar: 100 μm. NC, naïve control group; S, sevoflurane group; P, propofol group.