Data analysis
Patients were grouped based on short (≤ 3 days), intermediate (4-10
days), prolonged (>10 days) time to recovery defined by
achievement of clinical stability (TTS): resolution of fever <
38°C, respiratory rate < 22 breaths/min, systolic blood
pressure > 100 mmHg, extubated, and return of mental status
to baseline. Study groups were compared on demographic and clinical
characteristics, pharmacologic management and outcomes. Descriptive
analyses were performed using Kruskal-Wallis and chi-square test where
appropriate. Predictors for prompt recovery after controlling for
significant variables were analyzed by univariate and multivariable
logistic regression. A p value < 0.05 was considered
significant. Statistical analyses were performed using GraphPad Prism
v6.07 (San Diego, CA, USA) or SAS version 9.4 (SAS Institute, Cary, NC).