FIGURE 3. Phylogenetic tree based on temporal data of European isolates and their global links. Tree was adapted by NextStrain (3,891 complete genomes as of 29/12/2020). Colors represent GISAID clades (G: includes the S-D614G amino-acid substitution; GH: includes the S-D614G and the ORF3a-Q57H amino-acid substitutions; GR: includes the S-D614G and the N-G204R amino-acid substitutions; GV: includes the S-D614G and the S-A222V amino-acid substitutions; S: includes the ORF8-L84S amino-acid substitution; V: includes the NSP6-L37F and the ORF3a-G251V amino-acid substitutions; L: contains sequences close to the reference genome; O: contains sequences not clustered into any of the major clades). NextStrain clades are depicted on the branch junctions. The red circle represents the strain of the current study.