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Association of cesarean section and allergic outcomes among infants at 1 year of age: Logistics regression analysis using data of 104,065 fetal and children’s records from the Japan Environment and Children’s Study
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  • Hajime Maeda,
  • Koichi Hashimoto,
  • Hajime Iwasa,
  • Hyo Kyozuka,
  • Hayato Go,
  • Akiko Sato,
  • Yuka Ogata,
  • Tsuyoshi Murata,
  • Keiya Fujimori,
  • Kosei Shinoki,
  • Hidekazu Nishigori,
  • Seiji Yasumura,
  • Mitsuaki Hosoya
Hajime Maeda
Fukushima Medical University School of Medicine

Corresponding Author:[email protected]

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Koichi Hashimoto
Fukushima Medical University School of Medicine
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Hajime Iwasa
Fukushima Medical University School of Medicine
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Hyo Kyozuka
Fukushima Medical University School of Medicine
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Hayato Go
Fukushima Medical University School of Medicine
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Akiko Sato
Fukushima Regional Center for the Japan Environmental and Children's Study
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Yuka Ogata
Fukushima Regional Center for the Japan Environmental and Children’s Study
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Tsuyoshi Murata
Fukushima Medical University School of Medicine
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Keiya Fujimori
Fukushima Medical University School of Medicine
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Kosei Shinoki
Fukushima Regional Center for the Japan Environmental and Children’s Study
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Hidekazu Nishigori
Fukushima Medical University School of Medicine
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Seiji Yasumura
Fukushima Medical University School of Medicine
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Mitsuaki Hosoya
Fukushima Medical University School of Medicine
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Abstract

Background: Globally, the incidence of allergic diseases is increasing along with cesarean delivery rates. Data regarding the association between cesarean delivery and allergic diseases are inconsistent. Here, we aimed to clarify the association between cesarean delivery and the development of asthma, atopic dermatitis, wheezing, and eczema. Methods: We used data from the Japan Environment and Children’s Study. The data included were those of 104,065 fetal records and their children. Information about the mode of delivery, asthma, atopic dermatitis, wheezing, and eczema was obtained from questionnaires and medical record transcripts. Multiple logistic regression analysis was used to assess the association between cesarean delivery and asthma, atopic dermatitis, wheezing, and eczema risk among infants at 1 year of age. Results: We included 74,639 subjects in this study, wherein 18.4% underwent cesarean deliveries. After adjusting for the perinatal, socioeconomic, and postnatal confounding factors, children born by cesarean delivery had no increased risk of developing asthma [95% confidence interval (CI) 0.84–1.08], atopic dermatitis (95% CI, 0.92–1.13), wheezing (95% CI, 0.94–1.04), or eczema (95% CI, 0.94–1.05). Conclusions: This nationwide cohort study found no association between cesarean delivery and asthma, atopic dermatitis, wheezing, and eczema among infants at 1 year of age. However, further studies are needed to evaluate whether cesarean delivery plays a role in the development of allergic diseases.