Introduction
MANEC is a neoplasm characterized by significant histological heterogeneity and is characterized by the simultaneous presence of both adenocarcinomatous and neuroendocrine differentiation; their definition includes each component found in at least 30% of the tumor. (1) They most commonly arise in the colon, appendix, rectum or stomach, however, a limited number of MANECs have been reported to originate in the gallbladder. (2) Due to the low frequency of this histotype, only a small number of cases have been described, and there is no established therapeutic strategy. Here we present a case of the patient with MANEC of anal region.