Abstract
Neck tumors are rare fetal conditions. They can receive their growth
stimuli by activating missense mutations characterizing disorders with
benign overgrowth, collectively known as
PIK3CA-Related-Overgrowth-Spectrum. This results in segmental overgrowth
with phenotypic variation, genetic heterogeneity or tissue specific
distribution. Thus, clinical and molecular diagnosis as well as
treatment remains challenging.