Physical Manifestations of UBA 1 Mutations and VEXAS
Since the gene for UBA 1 is present on the X Chromosome, it is therefore justified that the frequency of VEXAS is substantially more in males as compared to females. Individuals who presented with these mutations displayed certain akin clinical features:
In addition to these, hematologic aberrations were also reported:
Please note that the primary source of the data for this section is David D. Beck et al’s reporting in The New England Journal of Medicine.