Investigation on the relationship between BVAS and variables
tested
In patient group,
Spearman
correlation analysis shown that MPO-AAV disease activity measured with
BVAS statistically significantly correlated with the level of
percentage
of PAD4+ neutrophil in all neutrophils, MFI of
PAD4+neutrophils, NETs, C5a and MPO-ANCA
(r =0.913, p <0.0001; r =0.881,p <0.0001; r =0.473, p =0.0021;r =0.666, p <0.0001 and r =0.869,p <0.0001, respectively) (Table II). There was neither
significant correlation between BVAS and the patient age, and nor
between BVAS and disease duration (r =0.011, p =0.9482 andr =0.085, p =0.5865, respectively) (Table II). Nevertheless,
multiple linear regression analysis found only percentage of
PAD4+ neutrophil and MPO-ANCA had independent
correlations with BVAS (p =0.0053 and p =0.0007,
respectively) (Table II).