Introduction
Hereditary spherocytosis (HS) is the most common cause of hemolytic anemia due to defects in the blood cell membrane. Total splenectomy is the most effective treatment modality for moderate or severe HS, but young children are at risk of post-splenectomy infections. Partial splenic embolization (PSE) might significantly improve the effects of hemolysis in HS patients while preserving partial splenic function. However, due to the poor controllability of the scope of interventional embolization, PSE in pediatric HS had not been widely studied and applied. The present study is the first to propose that optimized PSE procedure to treat pediatric HS patients, which named super-selective partial splenic embolization (SPSE). We investigated the feasibility and effectiveness of SPSE.