Introduction
Hereditary spherocytosis (HS) is the most common cause of hemolytic
anemia due to defects in the blood cell membrane. Total splenectomy is
the most effective treatment modality for moderate or severe HS, but
young children are at risk of post-splenectomy infections. Partial
splenic embolization (PSE) might significantly improve the effects of
hemolysis in HS patients while preserving partial splenic function.
However, due to the poor controllability of the scope of interventional
embolization, PSE in pediatric HS had not been widely studied and
applied. The present study is the first to propose that optimized PSE
procedure to treat pediatric HS patients, which named super-selective
partial splenic embolization (SPSE). We investigated the feasibility and
effectiveness of SPSE.