Meta-analysis on obstetric and fetal outcomes
Meta-analysis showed a significantly higher chance on preterm delivery
(OR 6.7 95% CI 5.1- 9.1), cesarean section (OR 2.6, 95% CI 1.7-3.9),
preeclampsia (OR 3.8, 95% CI 2.2-6.5) and small for gestational age
neonates (OR 2.6, 95% CI 1.6-4.2) in pregnant women with liver
cirrhosis compared to pregnant women without liver cirrhosis (Figure 2).
There was high heterogeneity in the analyses of preterm delivery,
cesarean section and small for gestational age. The studies thought to
be responsible for most heterogeneity were the studies of Rasheed et al.
and Flemming et al., based on their study design, patient
characteristics and inclusion criteria (see discussion). Sensitivity
analyses after elimination of these two studies did lower the
I2 on the outcomes preterm delivery
(I2 before 94%, after 23%) and small for gestational
(I2 before 71%, after 0%). The sensitivity analysis
of cesarean section maintained moderate heterogeneity
(I2 before 95%, after 68%).