Design
Observational, prospective, longitudinal study on a tertiary PICU (14 bed with and a mean of 800 admissions per year). It was done in children with asthma exacerbation and PICU admission (from October 2017 to October 2019). The ethics committee from Hospital Infantil Universitario Niño Jesús approved it. The data were obtained from clinical registers and was performed following the principles of the Declaration of Helsinki. The authors assume responsibility for the accuracy and completeness of the data and analyses and for the fidelity of the report. The attending in charge decided the clinical management based on the clinical protocols applied in our unit. Children with severe comorbidities or previous disease were excluded.