Patients
This 10-year prospective study (2010-2019) included children aged under 16 years who were referred to our allergy unit for an evaluation of BL DHR.Reactions were classified as IR or NIR according to established criteria5,10. For IRs, ST (prick tests and intradermal tests) were carried out as recommended, with some modifications19. For NIRs, we also followed the pediatric adaptation5,8,21 of the 2004 general recommendations made by the European Network for Drug Allergy (ENDA) and the European Academy of Allergy and Clinical Immunology (EAACI)20, that is, ST (delayed intradermal tests and patch tests) followed by DPT when appropriate.