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\begin{document}

\title{Antibiotic Stewardship Program's potential impacts on financial and
clinical outcomes in a public hospital: a Real-World study}



\author[1]{Rodrigo Garbero}%
\author[1]{Nathalia Lobão Barroso de Souza Silveira}%
\author[2]{Analice Alves Simões}%
\author[2]{Gabriela Alves Martins}%
\author[2]{Ludmilla Vale da Cruz}%
\author[2]{Vinícius Gabriel Monteiro von Zuben}%
\author[2]{Camila Serra Rodrigues}%
\author[2]{Natan da Silva}%
\author[2]{Derek Chaves Lopes}%
\affil[1]{Base Hospital of the Federal District}%
\affil[2]{Superior School of Health Sciences}%


\vspace{-1em}



  
  \date{May 08, 2024}


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\begin{abstract}
Background: In times of antibiotic resistance, Antimicrobial Stewardship
Programs (ASP) emerge as a strategy to improve clinical outcomes and
hospital resource management. Methods: The study was conducted on a
single-center retrospective cohort of adult inpatients admitted to a
public hospital in Brazil's capital and submitted to ASP from September
2018 to April 2019, aiming to assess the clinical and economic impact of
following ASP instructions. Results: The medical records of 449 patients
were included. Mean age was 54.92 years, with a predominance of male sex
273 (60.93\%), and 374 (83.48\%) had comorbidities. Only 52.56\% of the
prescriptions followed the guidelines of ASP. The study demonstrated a
significant improvement in clinical outcomes, such as a reduction of
mortality (p=0.01), of hospital length of stay (p\textless{}0.01) and of
ICU admissions (p\textless{}0.01). We also detected potential savings
per patient provided by compliance with ASP's recommendations.
Conclusion: The present study was able to demonstrate positive clinical
outcomes associated with the implementation of an ASP in a real-world
scenario.%
\end{abstract}%



\sloppy


\textbf{Title page - International Journal of Clinical Practice}

\textbf{Title:} Antibiotic Stewardship Program's potential impacts on
financial and clinical outcomes in a public hospital: a Real-World study

\textbf{Running title:} ASP's potential impacts: a Real-World study

\textbf{Authors' Information:}

\emph{Rodrigo de Freitas Garbero *} (Corresponding author)\selectlanguage{ngerman}¶

Affiliation: Base Hospital Institute of Federal District, Brasília,
Brazil.

Email: r.galuvi@gmail.com

ORCID: 0000-0001-6314-5256

Tel: +55 61 9271-1578

Address: SMHS - Área Especial, Q. 101 - Asa Sul, Brasília, Federal
District, 70330-150, Brazil

Nathalia Lobão Barroso de Souza Silveira¶

Affiliation: Clinical Pharmacy Department, Base Hospital Institute of
Federal District, Brasília, Brazil.

Email: nathlobao@gmail.com

ORCID: 0000-0001-8182-4543

Analice Alves Simões

Affiliation: Faculty of Medicine, Superior School of Health Sciences,
Brasília, Brazil.

Email: analice.simoes95@gmail.com

ORCID: 0000-0002-7618-8105

Gabriela Alves Martins

Affiliation: Faculty of Medicine, Superior School of Health Sciences,
Brasília, Brazil.

Email: gabriela.almartins@gmail.com

ORCID: 0000-0001-6855-3283

Ludmilla Vale da Cruz

Affiliation: Faculty of Medicine, Superior School of Health Sciences,
Brasília, Brazil.

Email: ludmillavcruz@gmail.com

ORCID: 0000-0003-4969-5133

Vinícius Gabriel Monteiro von Zuben

Affiliation: Faculty of Medicine, Superior School of Health Sciences,
Brasília, Brazil.

Email: mvzuben@gmail.com

ORCID: 0000-0002-4050-409X

Camila Serra Rodrigues

Affiliation: Faculty of Medicine, Superior School of Health Sciences,
Brasília, Brazil.

Email: camilaserrarodrigues@gmail.com

ORCID: 0000-0002-3390-2655

Natan Teixeira da Silva

Affiliation: Faculty of Medicine, Superior School of Health Sciences,
Brasília, Brazil.

Email: natan307.nt@gmail.com

ORCID: 0000-0002-2570-1220

Derek Chaves Lopes

Affiliation: Faculty of Medicine, Superior School of Health Sciences,
Brasília, Brazil.

Email: derek.lopes5@gmail.com

ORCID: 0000-0002-4382-2528

\textbf{Acknowledgements: -}

\textbf{Conflict of interest statement} : All authors declare that they
have no conflict of interest.

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