Supportive care
Pneumocystitis jirovecii prophylaxis with sulfamethoxazole/trimethoprim was routinely administered during the whole treatment time. In case of neutropenia prophylactic fluconazole p.o. was given. In case of febrile neutropenia, standard laboratory values were assessed, blood and urine cultures were extracted and a chest x-ray examination was performed. Patients were empirically treated with ofloxacin 10 mg/kg, ceftriaxone 100 mg/kg or augmentin 80-100 mg/kg. Dependent on the antibiogram meropenem 60 mg/kg or ceftazidime 100-120 mg/kg were added. Guidelines were provided for hyperleukocytosis and acute tumor lysis syndrome. Whole blood transfusions were only given if hemoglobin was < 7 g/dl. Platelet transfusions were not available.