Supportive care
Pneumocystitis jirovecii prophylaxis with sulfamethoxazole/trimethoprim
was routinely administered during the whole treatment time. In case of
neutropenia prophylactic fluconazole p.o. was given. In case of febrile
neutropenia, standard laboratory values were assessed, blood and urine
cultures were extracted and a chest x-ray examination was performed.
Patients were empirically treated with ofloxacin 10 mg/kg, ceftriaxone
100 mg/kg or augmentin 80-100 mg/kg. Dependent on the antibiogram
meropenem 60 mg/kg or ceftazidime 100-120 mg/kg were added. Guidelines
were provided for hyperleukocytosis and acute tumor lysis syndrome.
Whole blood transfusions were only given if hemoglobin was < 7
g/dl. Platelet transfusions were not available.