Effects of microinjection of LY235959 or NBQX into the insular cortex on the increase in circulating corticosterone evoked by restraint stress
LY235959 – Bilateral microinjection of the selective NMDA antagonist LY235959 (1 nmol/100 nL) did not alter the increase in circulating corticosterone caused by restraint stress (treatment: F(1,11) = 0.1106; time: F(1, 11) = 22.91; interaction: F(1,11) = 1.168) (Fig. 6). The baseline corticosterone release (before stress) of animals treated with LY235959 was not different from that of animals treated with aCSF (t = 1.219).
NBQX – Bilateral microinjection of the selective non-NMDA antagonist NBQX (1 nmol/100 nL) did not change the increase in corticosterone triggered by restraint stress (treatment: F(1,11) = 1.256; time: F(1,11) = 34.61; interaction: F(1,11) = 1.698) (Fig. 6). NBQX treatment did not change the baseline corticosterone release (before stress) of animals treated with NBQX compared to animals treated with aCSF (t = 0.1818).