In the present case, initially elevated IL-6, IL-8, IL-10, and IFN-γ levels were reduced to normal ranges following hemoadsorption with HA330. This indicated that this column was able to effectively reduce inflammatory cytokines levels in our treated patient. However, this approach was unable to effectively remediate HLH-related liver failure in this patient, whereas hemoadsorption combined with chemotherapy was found to be more effective than hemoadsorption alone. With respect to hemoadsorption, CytoSorbTM column [11] or endotoxin-binding polymyxin B- immobilized fiber column [12] hemoadsorption approaches have also been reported for the treatment of HLH. Cytokine adsorption associated with the CytoSorbTM column results in improvements in patient clinical condition and helps achieved symptom relief in affected individuals. Polymyxin B-immobilized fiber columns have also contributed to the recovery of circulatory dynamics associated with HLH. HA330 resin-based hemoadsorption has been reported to blunt both circulating and pulmonary cytokine storms in a model of endotoxin-induced porcine acute respiratory distress syndrome (ARDS) [4].