3 Results
3.1 The concentration of
D-serine in NAc was
decreased in depression susceptible mice
After a brief (10 minutes) daily exposure to a highly aggressive
resident mouse for 14 days, the
mice were divided into control group, depression susceptible group and
depression unsusceptible group with 10 mice in each group according to
the results of behavioral experiments (data not shown). Then the
prefrontal cortex, amygdala and NAc of each group were extracted
respectively. Finally, the average content of D-serine in three
different brain regions was calculated by high performance liquid
chromatography (HPLC). The results showed that there was no significant
difference in D-serine content in the prefrontal cortex and amygdala of
the control group, depression susceptible group and depression
unsusceptible group. However, compared with the control group and the
depression unsusceptible group, the content of D-serine in the NAc of
depression susceptible group was significantly reduced (n = 10, P
< 0.01 vs. control or unsusceptible; Figure 1A). The results
showed that the concentration of D-serine in NAc was decreased in
depression susceptible group.