3.6.2 D-Serine in the NAc region modulates Synaptic plasticity
Furthermore, the NMDAR-LTD in the NAc were compared in the control, CSDS, CSDS+ fluoxetine and CSDS+D-serine(2,5ug/preside) groups. Chronic fluoxetine or D-serine treatment significantly increased the amplitude of LTD and reversed the impaired NMDAR-LTD in NAc of CSDS mice (Figure 6.2 A, B, C and D). Taken together, the electrophysiological data showed that synaptic plasticity in the NAc is disrupted in CSDS mice, which was reversed by D-serine treatment, backing a role for NMDAR-LTD in the NAc in depression.