2.15 Materials
D-serine, K252a and fluoxetine were purchased from Sigma (St. Louis, MO, USA). D-serine and fluoxetine were dissolved in 0.9% saline. K252a was dissolved in DMSO to 25mM and in ethanol to 5 mM. The dosages of D-serine (2ug/perside,5ug/perside ), fluoxetine (5ug/perside ) and K252a (5ug/perside) were chosen based on previous reports with some modifications(B Jiang et al., 2012). D-serine, K252a and fluoxetine were stereotaxically injected into the bilateral NAc. The repeated drug treatment of mice was performed once daily between 9:30 and 10:30 am.