3.6.2 D-Serine in the NAc region modulates Synaptic plasticity
Furthermore, the NMDAR-LTD in the NAc were compared in the control,
CSDS, CSDS+ fluoxetine and CSDS+D-serine(2,5ug/preside) groups. Chronic
fluoxetine or D-serine treatment significantly increased the amplitude
of LTD and reversed the impaired
NMDAR-LTD in NAc of CSDS mice (Figure 6.2 A, B, C and D). Taken
together, the electrophysiological data showed that synaptic plasticity
in the NAc is disrupted in CSDS mice, which was reversed by D-serine
treatment, backing a role for NMDAR-LTD in the NAc in depression.