3.3 Chronic D-serine treatment restored the CSDS-induced
depressive symptoms
We further utilized the CSDS model to characterize the antidepressant
effects of D-serine, which mimics many symptoms of depression in
human(Rouhiainen et al., 2019). As shown in Figure 3A, all mice spent
similar time in the interaction zone during the target absent trial.
CSDS-defeated mice spent significantly less time in the interaction zone
compared to vehicle-treated mice when the CD1 aggressor was present.
Interestingly, 14 days of administration with D-serine significantly
reversed the CSDS-induced social avoidance behavior, peculiarly at 5
ug/perside, similar to fluoxetine. In addition, CSDS induced a
significantly decrease in sucrose preference, compared with control
group. 14-day administration with D-serine in CSDS-susceptible mice
prompted an obvious increase of sucrose intake (Figure 3B).
Collectively, these results revealed that D-serine produces
antidepressant effects in depressive mice.