Type-4 phosphodiesterase (PDE4) blockade prevents NETosis in cystic
fibrosis
Running title: Phosphodiesterase 4 inhibition in cystic fibrosis
Licia Totania,
Concetta Amorea, Antonio Piccolia,
Giuseppe Dell’Elbaa, Angelo Di
Santoa, Roberto Plebanib,c, Romina
Pecce b,c, Nicola Martellia, Ida De
Finoe, Serena Ranuccie, Alice
Rossie, Paolo Morettid, Alessandra
Bragonzie, Mario Romanob,c, Virgilio
Evangelistaa
aLaboratory of Vascular Biology and Pharmacology,
Fondazione Mario Negri Sud, Santa Maria Imbaro (CH);bDepartment of Medical, Oral and Biotechnological
Sciences, G. D’Annunzio University of Chieti-Pescara;cCentre for Advanced Studies and Technology (CAST), G.
D’Annunzio University of Chieti-Pescara; dCystic
Fibrosis Centre, S. Liberatore Hospital, Atri (TE); eInfection and Cystic Fibrosis Unit, Division of Immunology,
Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific
Institute, Milano, Italy
E-mail:
totani58licia@gmail.com (L.T.); a.concetta66@hotmail.it. (C.A.);
piccolicacciatore@libero.it
(A.P.);
giuseppedellelba@gmail.com
(G.D.E.);
disatangelo@gmail.com
(A.D.S.); robplebani@gmail.com (R.P.); romanella712@gmail.com (R.P.),
nicolamtb@libero.it (N.M.); ranucci.serena@hsr.it (S.R.);
defino.ida@hsr.it (I.D.F.); rossi1.alice@hsr.it (A.R.);
dr.morettipaolo@libero.it
(P.M.) bragonzi.alessandra@hsr.it (A.B.),
mromano@unich.it (M.R.),
evangelista59gino@gmail.com.
(V.E.).