METHODS
Subjects :
The study protocol was approved by the Local Ethics Committee of Faculty of Medicine, University of Alexandria (0201018) that is conformed to the ICH GCP guidelines. All participants provided a written informed consent to inclusion of the clinical and laboratory data for research purposes upon fulfilling the study enrollment criteria.
Thirty MS cases, who presented to the MS Clinic of Alexandria University Hospital, were enrolled in our study. These were diagnosed clinically according to revised McDonald criteria 2017. (11) In addition, complete neurological and systemic examination including expanded disability status scale (EDSS). (12)
A cross matching control group of twenty healthy subjects of similar age and sex were included.