Conclusion
In conclusion, the results of our study show that dynamic thiol
disulfide and TrxR enzyme levels play an important role in the
pathogenesis of CKD and appear to be associated with oxidative stress.
Measurement of dynamic thiol-disulfide levels by using colorimetric
method can contribute to the diagnosis and follow-up of the disease as a
marker, because, it is easily applicable in routine clinical
biochemistry laboratories and related with disease severity in CKD
patients. Another result obtained in this study is the remarkable change
in thiol values caused by albumin correction. It has shown that volume
correction, which may be caused by this dialysis process, should be
taken into account in studies dealing with plasma thiol values and the
final results should be given after the correction process.