The suppression of Brd4 inhibits peripheral plasma cell
differentiation and exhibits therapeutic potential for systemic lupus
erythematosus
Shan Zeng1,2,a, Qian Qiu1,a, Yi
Zhou1,a, Youjun Xiao1, Jingnan
Wang1, Ruiru Li1, Siqi
Xu1, Maohua Shi1, Cuicui
Wang3 , Yu Kuang1, Minxi
Lao1, Xiaoyan Cai3,*, Liuqin
Liang1, *, Hanshi
Xu1,*
1 Department of Rheumatology and Immunology,
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou,
Guangdong, China
2 Department of Rheumatology, The First
Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China
3 Department of Rheumatology, Guangzhou First
People’s Hospital, School of Medicine, South China University of
Technology, Guangzhou, Guangdong, China
a ZS, QQ and ZY contributed equally to this work
Running Title: Brd4 and plasma cell in SLE
Key Words: SLE, BRD4, B cell, PFI-1
word count: 5334
* Correspondence and requests for
materials should be addressed to:
Hanshi Xu, M.D., Ph.D. E-mail: xuhanshi@mail.sysu.edu.cn
Liuqin Liang, M.D, E-mail: lliuq@mail.sysu.edu.cn
Xiaoyan Cai, M.D, E-mail: caixytracy@126.com