The suppression of Brd4 inhibits peripheral plasma cell differentiation and exhibits therapeutic potential for systemic lupus erythematosus
Shan Zeng1,2,a, Qian Qiu1,a, Yi Zhou1,a, Youjun Xiao1, Jingnan Wang1, Ruiru Li1, Siqi Xu1, Maohua Shi1, Cuicui Wang3 , Yu Kuang1, Minxi Lao1, Xiaoyan Cai3,*, Liuqin Liang1, *, Hanshi Xu1,*
1 Department of Rheumatology and Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
2 Department of Rheumatology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China
3 Department of Rheumatology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China
a ZS, QQ and ZY contributed equally to this work
Running Title: Brd4 and plasma cell in SLE
Key Words: SLE, BRD4, B cell, PFI-1
word count: 5334
* Correspondence and requests for materials should be addressed to:
Hanshi Xu, M.D., Ph.D. E-mail: xuhanshi@mail.sysu.edu.cn
Liuqin Liang, M.D, E-mail: lliuq@mail.sysu.edu.cn
Xiaoyan Cai, M.D, E-mail: caixytracy@126.com