AUTHOR CONTRIBUTIONS
Z.S., and Q.Q. performed the majority of the experiments and analyzed
and interpreted the data. Z.Y., L.R., W.C., X.Y., L.M. and K.Y.
collected clinical samples and analyzed and interpreted the data. X.S.
and S.M. performed the animal experiments. Z.S., L.L., C. X and H.X.
contributed to the study concept and design. Z.Y., L.L. and H.X. drafted
the manuscript. C.X., L.L. and H.X. contributed to study supervision.