AUTHOR CONTRIBUTIONS
Z.S., and Q.Q. performed the majority of the experiments and analyzed and interpreted the data. Z.Y., L.R., W.C., X.Y., L.M. and K.Y. collected clinical samples and analyzed and interpreted the data. X.S. and S.M. performed the animal experiments. Z.S., L.L., C. X and H.X. contributed to the study concept and design. Z.Y., L.L. and H.X. drafted the manuscript. C.X., L.L. and H.X. contributed to study supervision.