L-TGL (TGL ≤ 5.5 g/L) patients L-TGL (TGL ≤ 5.5 g/L) patients L-TGL (TGL ≤ 5.5 g/L) patients H-TGL (TGL > 5.5 g/L) patients H-TGL (TGL > 5.5 g/L) patients H-TGL (TGL > 5.5 g/L) patients
Deceased Patients Patients alive p value Deceased Patients Patients Alive p value
N = 10 2 NA 22 62
Sex (M/F) 6/4 1/1 NA 11/11 22/40 0.31
Age (years) median [range] 65 [57-80] 66 [55-78] NA 72 [56-85] 69 [21-89] 0.07
Lymphoma Ann-Arbor-Stage
I 0 0 NA 0 16 0.02
II 1 0 NA 2 13 0.35
III 2 2 NA 4 11 1
IV 7 0 NA 16 22 0.09
Central nervous system involvement (CNS) 2 0 NA 1 4 1
Richter syndrome (RS) 0 0 NA 2 0 0.07
International Prognostic Index (IPI)/Risk group (n=) 8 (CNS excluded) 2 19 (CNS and RS excluded) 58 (CNS excluded)
(0-1) Low 1 0 NA 0 7 0.4
(2) Low-Intermediate 1 0 NA 2 26 0.06
(3) High-Intermediate 2 2 NA 5 14 1
(4-5) High 4 0 NA 12 11 0.02
Chemotherapy Regimen
First-line
RCHOP 8 (80%) 2 (100%) 0.11 21 (95%) 54 (87%) 0.85
RMPV 2 (20%) 0 NA 1 (5%) 4 (6%) 1
ABVD 0 0 NA 0 3 (5%) 0.56
Second-line 7 (70%) 2 (100%) NA 11 (50%) 17 (27%) 0.55
Third-line 3 (30%) 0 NA 4 (18%) 3 (5%) 0.09
Fourth-line 1 (10%) 0 NA 1 (5%) 0 0.27
Total gammaglobulin level (g/L) median [range] 5.2 [2.7-5.5] 4.15 [3.8-4.5] NA 9.25 [5.9-18.3] 9.15 [5.9-17.9] 0.82
Immunoglobulin isotype levels, n 7 1 NA 13 33 1
IgG level (g/L) median [range] 5.45 [2.8-5.45] 4.44 NA 11.4 [6.48-13.8] 9.06 [6.38-14.6] 0.16
IgA level (g/L) median [range] 0.61 [0.35-5.91] 1.11 NA 1.49 [0.28-2.16] 1.42 [1.12-2.47] 0.43
IgM level (g/L) median [range] 0.46 [0.2-3.7] 0.2 NA 1.26 [0.25-1.35] 0.96 [0.18-1.44] 0.57
CRP level (g/L) median [range] 26.5 [3-116] 65 NA 37 [3-119] 11 [3-237] 0.19
Ferritin level (µg/L) median [range] 538.5 [73-1628] 112 NA 217.5 [93-1496] 151 [4-3472] 0.47
Albumin level (g/L) median [range] 33.8 [24-40.7] 32 36 [23-46] 39 [16-50] 0.20
AG-Ratio median [range] 6.79 [4.62-12.22] 7.63 NA 4.15 [1.85-7.13] 4.3 [1.7-6.61] 0.64
LDH (Unit/L) median [range] 285 [156-2784] 776.5 [537-1016] NA 373 [162-2793] 278 [132-10091] 0.69
Lymphocytes count (G/L) median [range] 0.8 [0.2-2.58] 0.62 [0.29-0.95] NA 0.85 [0.27-7.56] 1.26 [0.18-7.56] 0.83