Introduction
Lentigines are brown macules which develop due to increased
proliferation of melanocytes at the dermo-epidermal junction. They
commonly occur in healthy people but can also be seen in genodermatoses
such as Noonan syndrome with multiple lentigines. Eruptive lentigines
have previously been described in the context of inflammatory
dermatoses, 1 phototherapy, 2 and
immunomodulatory therapy. 3 Acral eruptive lentigines
have been described following chemotherapy 4 or as a
paraneoplastic phenomenon. 5 We report three cases of
acral lentiginosis in children following chemotherapy for acute
lymphoblastic leukaemia (ALL) which have persisted following cessation
of chemotherapy, despite avid photoprotection. All patients remain in
remission from ALL.