Introduction
Pump failure was a fatal comorbidity of acute myocardial infarction (AMI), which consists of cardiac failure and cardiogenic shock (CS). It was reported that the incidence of pump failure was from 6.5% to 8.3%1. Over the past few decades, the percutaneous coronary intervention (PCI) as a invasive treatment has been increasingly prominent. Howerver, mortality of AMI complicating pump failure was not obviously declining with emergency revascularization.
Intraaortic balloon pump (IABP) was an important ventricular support device for the treatment of heart diseases. The use of IABP contributed to improve peripheral blood circulation, as well as, to stabilize circulatory hemodynamics and increase coronary artery blood perfusion2. Especially when severe hypotension and acute cardiac insufficiency occurred in emergency during PCI, IABP adjuvant therapy significantly improved the hemodynamic disturbance3.
The sharp decrease of cardiac output and blood pressure plummets resulted in renal perfusion insufficiency, and continuous ischemia and hypoxia in the kidney. Energy metabolism disorder in renal tubular epithelial cells made the acute tubular necrosis happened. The necrotic renal tubule epithelium fell off that blocked the tubule, which affectd the glomerular filtration rate 4. In patients with AMI complicating with pump failure, the incidence of acute kidney injury (AKI) was as high as 50%, and the mortality rates of patients with AMI once combined with AKI were significantly increased5,6. However, the effects of duration of using IABP on renal function have been rarely reported, and need to be confirmed by further studies.
The purpose of this study was to observe the effect of IABP treatment on renal function and prognosis in patients with AMI complicating pump failure at different times, and to explore the optimal therapeutic duration of IABP treatment in patients with AMI combined with pump failure, so as to provide scientific basis for clinical treatment of patients with AMI complicated with pump failure.