Introduction
Pump failure was a fatal comorbidity of acute myocardial infarction
(AMI), which consists of cardiac failure and cardiogenic shock (CS). It
was reported that the incidence of pump failure was from 6.5% to
8.3%1. Over the past few decades, the percutaneous
coronary intervention (PCI) as a invasive treatment has been
increasingly prominent. Howerver, mortality of AMI complicating pump
failure was not obviously declining with emergency revascularization.
Intraaortic balloon pump (IABP) was an important ventricular support
device for the treatment of heart diseases. The use of IABP contributed
to improve peripheral blood circulation, as well as, to stabilize
circulatory hemodynamics and increase coronary artery blood
perfusion2. Especially when severe hypotension and
acute cardiac insufficiency occurred in emergency during PCI, IABP
adjuvant therapy significantly improved the hemodynamic
disturbance3.
The sharp decrease of cardiac output and blood pressure plummets
resulted in renal perfusion insufficiency, and continuous ischemia and
hypoxia in the kidney. Energy metabolism disorder in renal tubular
epithelial cells made the acute tubular necrosis happened. The necrotic
renal tubule epithelium fell off that blocked the tubule, which affectd
the glomerular filtration rate 4. In patients with AMI
complicating with pump failure, the incidence of acute kidney injury
(AKI) was as high as 50%, and the mortality rates of patients with AMI
once combined with AKI were significantly
increased5,6. However, the effects of duration of
using IABP on renal function have been rarely reported, and need to be
confirmed by further studies.
The purpose of this study was to observe the effect of IABP treatment on
renal function and prognosis in patients with AMI complicating pump
failure at different times, and to explore the optimal therapeutic
duration of IABP treatment in patients with AMI combined with pump
failure, so as to provide scientific basis for clinical treatment of
patients with AMI complicated with pump failure.