First Observation:
This 11-year-old girl had physical asthenia with diffuse bone pain and
vomiting. On clinical examination, there was an enormous splenomegaly
(14cm below the costal grill) with hepatomegaly at 11 cm and no palpable
adenopathy. Biologically, the Blood Count revealed hyperleukocytosis
(White Blood Cells: 400190/mm³), anemia (hemoglobin level: 7.7g/dl) and
moderate thrombocytopenia (platelet level 100,000/mm³). The myelogram
showed hyperplasia of the granular lineage and reactive hypoplasia of
the erythroblastic lineage containing 6% of blasts (figure 1). The
tumor lysis test is negative. The genetic study shows the presence of
the transcript BCR-ABL1. The child is actually stable with
regression of hepatomegaly and splenomegaly after receiving imatinib
100mg (1 capsule×4 / Days).