First Observation:
This 11-year-old girl had physical asthenia with diffuse bone pain and vomiting. On clinical examination, there was an enormous splenomegaly (14cm below the costal grill) with hepatomegaly at 11 cm and no palpable adenopathy. Biologically, the Blood Count revealed hyperleukocytosis (White Blood Cells: 400190/mm³), anemia (hemoglobin level: 7.7g/dl) and moderate thrombocytopenia (platelet level 100,000/mm³). The myelogram showed hyperplasia of the granular lineage and reactive hypoplasia of the erythroblastic lineage containing 6% of blasts (figure 1). The tumor lysis test is negative. The genetic study shows the presence of the transcript BCR-ABL1. The child is actually stable with regression of hepatomegaly and splenomegaly after receiving imatinib 100mg (1 capsule×4 / Days).