Cross-positivity analysis for four aPLs in APS patients
Among 151 APS patients, cross positivity of IgG, IgM, or IgA for aCL or aβ2GpI (a and b), as well as IgG or IgM for each of the four aPLs (c and d) were demonstrated with Venn diagram in figure 2. For patients positive for aCL, 16 were positive only for IgA. Concerning IgG isotype, aCL and aAnxV IgG were most often positive among APS patients. As for IgM isotype, there were 12 (7.9%) patients who were test positive only for aAnxV, and 4 (2.6%) were positive only for aPS/PT.
The number of patients positive only for each of the five non-criterial aPLs was also calculated among SPAPS and SNAPS patients (not shown). Totally 12 patients for aCL IgA, 9 for aAnxV IgG, 5 for aAnxV IgM, 3 for aPS/PT IgM, 1 for aPS/PT IgG, and 1 for aβ2GpI IgA were observed. On the other hand, among all 14 SNAPS patients, 7(50%) were positive for extra criteria aPLs. ACL IgA and aAnxV IgM each identified 3 of these patients individually, while 1 patient was positive for aPS/PT IgM and aβ2GpI IgA.