Conclusion
In conclusion, detection of aCL IgA, aβ2GPI IgA, aAnxV IgG/M, and aPS/PT IgG/M as biomarker provide additive value in APS diagnosis, especially aCL IgA and aAnxV IgG. Detecting aCL IgA and aAnxV IgM assist in identifying seronegative APS patients. IgG of aANxV or aPS/PT was significantly associated with LA, and IgG aANxV was linked with stroke, which would assist in risk prediction for APS patients in medical practice.