5. Conclusion
In summary, our findings suggest that high levels of adipose tissue in CT parameters including TATI, VATI, and SATI may be a possible predictor of OS in patients with mRCC treated with targeted therapy, and also SMI may be a predictor for PFS. Considering the widely disparate results of the studies, the prognostic value of body composition (BMI, SATI, VATI, SMI) and their alterations in the course of mRCC should be evaluated in a larger patient population with prospective design to validate cut-off values for these parameters. If our results are corroborated by future trials, the measurement of VBC parameters and incorporation of those into the current scoring systems would provide better prognostication and personalized treatment in mRCC.