Figure 1: Domain swap conformational change in a dimer interface arising from a single mutation. The figure shows a superposition of two experimental structures (T1109, mutant and T1110, wild-type) with different colors (green and turquoise) depicting different subunits of each structure. In the wild-type structure, the C-terminal region (colored blue in the front turquoise subunit) of each monomer folds back towards the same subunit, making intra-subunit contacts. In the presence of the mutation (yellow, Asp Ala), the C terminal region (colored red in the front subunit) has a substantially altered conformation making inter-subunit contacts. Groups from seven labs succeeded in reproducing this effect, mostly using enhanced sampling variants of AlphaFold2.