Statistical analyses
Descriptive statistics were used to summarize patient characteristics. Host and disease-related factors, as well as IMI incidence, were compared between patients treated from 2006-2015 and those treated from 2016-2020 using a Chi-square, Fisher’s exact, or Student t-test, as appropriate. Host and disease related factors predictive of IMI for patients with and without a diagnosis of proven/probable IMI over the entire time period (2006-2020) were assessed by univariable and multivariable linear regression. For all comparisons, p values were considered significant at alpha < 0.05. All statistical analyses were performed using Intercooled Stata, version 14 (Stata Corp, College Station, TX).