10. Consider limitations of the model
It is important to bear in mind that models are predictions and
therefore have their limitations. This has to be considered in
interpretation and explanation of e.g. in structure-based biological and
medical phenomena. Describe any limitations of the generated model and
limitations in the interpretation and inference based on it.
Example: The model is considered to be rather reliable, as
indicated by validation scores. Since the template matches along with
the entire sequence and has 53% sequence identity, the scaffolding and
conserved parts are likely of high quality. The orientation of loop at
position 216-220 is somewhat unsure. This region has relatively high B
factor values in the template (>60 Å2)
and the additional residues on the surface loop have plenty of degrees
of freedom. The structure was minimized to solve clashes and
non-favorable stereochemistry.