Titration of FiO2 after CAR test:
Titration of inspired oxygen was continued as per unit protocol, relying on combined monitoring of crRTO (targeted between 60 to 80%) and SpO2 (targeted between 86% to 94%), in those infants with maintained CAR, and who had successful weaning of supplemental oxygen more than 20% below the starting FiO2 by the end of the CAR test. FiO2 could be weaned stepwise by 0.02 FiO2 if crRTO was >80%, even when SpO2 is within acceptable target saturation(20). Mild desaturations and short self-resolved hypoxemic episodes were observed without intervention as long as crRTO was maintained within target limits.