Experimental design and statistical analysis
All experiments with at least three biological replications were analyzed by Graphpad Prisim 9.0 statistical software using one-way or two-way analysis of variance (ANOVA). The values presented were the means ± one standard deviation (SD) of three biological replicates.P values were corrected with Bonferroni,* P < 0.05, ** P < 0.01, *** P < 0.001, ****P < 0.0001.