Results
From ROC curve analysis, the optimal cut-off value of the nodal volume
was 3.95 cm3, to predict the disease prognosis, in
terms of overall survival and metastatic-free survival (p=
<0.001 and p=0.005, respectively), but not the disease-free
survival (p=0.241). For the multivariable analysis, the nodal volume,
but not TNM staging, was a significant prognostic factor for distant
metastasis