Statistical Analysis:
The results were analyzed using  SPSS software (version 23.0; SPSS, Chicago, IL, USA) and Prism 8 for OS X (version 8.4.3 GraphicPad Software, LLC) used for figures drawing.
The continuous variables were expressed as Mean ± SD . The results were compared using a paired student’s t-test. Median {interquartile ranges (IQR)} was used as appropriate. The Chi-square test was used to analyze the categorical variables, and a 95% confidence interval was reported. The potential impact and risk of renal and hepatic injury described by Cox hazard regression model and 95% Confidence Interval. All statistical analysis was significant at p-value < 0.05.