COX-2 expression levels were higher in post-CT tumors and inversely correlated with MYCN amplification
All the NB and GNB samples were positive for the COX-2 protein expression (n = 77). COX-2 expression levels in the post-CT samples were significantly higher than the those observed in the pre-CT unpaired samples (p-value = 0.0097; Figure 1) and inversely correlated with MNA (Spearman ρ = -0.693, p-value = 0.038). In the paired samples, COX-2 expression in post-CT was slightly higher than in pre-CT (p-value = 0.4076). In the multivariate analysis, no correlation was observed among the COX-2 expression and clinical factors. OS inversely correlated with age at diagnosis (Spearman ρ = -0.295, p-value = 0.009), stage (ρ = -0.422, p < 0.0001), and MNA status (ρ = -0.562, p < 0.0001).