Patient data
The clinical data of a total of 91 patients were analyzed in this study (TABLE 1). The patients’ outcomes were examined until September 2019, 60 months after the inclusion of the last patient. The average age at diagnosis was 33.5 months, ranging from 0 to 13 years old, with 52 patients (58%) being diagnosed after 18 months of age. Thirteen cases (14%) were diagnosed as GN. NB tumors were classified according to the INSS 7, with stage 4 as the most frequent (44% cases), which was coincident with unfavorable histological features (48% cases). Relapse occurred in approximately 35 cases (39%); in total, 30 patients (33%) died of disease, with 25 patients dying (28%) within a 5-year follow-up period. The MNA status was determined for 84 subjects (Supplemental Figure S2). Among them, 9 cases (11%) were classified as having amplified MYCN , with > 10MYCN copies.