Effect of different doses of dexmedetomidine on the median effective concentration of propofol during gastrointestinal endoscopy:a randomized controlled trial
Running Title: EC50 of propofol with dexmedetomidine
Hai-yan Chen, M.D.*, Fang Deng, M.D.*, Shu-heng Tang, M.D.*, Wen Liu, M.D., Hua Yang, M.D. #, Jin-Chao Song, M.D.#
Department of Anesthesiology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China
* Hai-yan Chen, Shu-heng Tang and Fang Deng, contributed equally to this work.
#Corresponding Author:
Jin-chao Song, Department of Anesthesiology, Shidong Hospital of Shanghai, University of Shanghai for Science and Technology, Shiguang Rd., No. 999, Shanghai, China. E-mail:sjch2013@163.com
Hua Yang, Department of Anesthesiology, Shidong Hospital of Shanghai, University of Shanghai for Science and Technology, Shiguang Rd., No. 999, Shanghai, China. E-mail:yanghuayanghua1977@163.com
Data Availability Statement: The data of this study are available from the corresponding author, if the request is reasonable.
Funding: The Health Committee and the Science and Technology Commission of Yangpu District, Shanghai: (YPM202105) and National Natural Science Foundation of China: (NSFC, No.81371511) supported this study..
Conflicts of interest: All authors in this work declare no conflict of interest.
Ethics approval: The trail is approved by the Committee on Ethics of Biomedicine Research, Shidong Hospital.
Patient consent statement: Each patient signs the informed consent before endoscopy
Permission to reproduce material from other sources: No material from other sources.
Trial registration: Chinese Clinical Trial Registry ChiCTR2100054402.