Measurements
In this study, baseline of HR and MAP are defined as the measured values
at 5 min after the patient was brought to the endoscopic room. HR, MBP
and SpO2 were monitored and recorded at the designated
time points: T0: baseline values; T1:
2.5 min after administration of dexmedetomidine; T2: 5
min after administration of dexmedetomidine (Dexmedetomidine
administration is over); T3: when propofol target plasma
concentration reached the target; T4: at scope
intubation; and T5-X: by 3 min intervals.
The endoscopic time were recorded. We defined the recovery time as the
interval time from cessation of TCI propofol to the time when patients
could respond readily to name spoken in normal tone (that is Observer’s
Assessment of Alertness/Sedation scale (OAA/S) = 5). Sedation-related
adverse events, such as postoperative nausea and vomiting, respiratory
depression, bradycardia, and hypotension, were also recorded.
The satisfaction of gastroenterologists (scored by 4, excellent; 3,
good; 2, fair; and 1, poor) and the satisfaction of patients (4, no
discomfort; 3, slightly uncomfortable; 2, extremely uncomfortable;
1,unacceptable) were assessed immediately after procedure and 30 minutes
after procedure, respectively. [7,10].
The average percent change from baseline in HR and MAP, were compared
among three groups. In this study, we defined the calculation formula of
percent change from baseline at the fixed time points = (HRT1-x –HR T0)/ HR T0*
100 and (MBPT1-x – MBPT0)/
MBPT0*100. [7,10].