WHAT THIS STUDY ADDS -
1. Combination medication of propofol with dexmedetomidine reduced the EC50 of TCI propofol during gastrointestinal endoscopy compared with administration of propofol without dexmedetomidine.
2. A 0.5-1 μg/kg dexmedetomidine caused a decrease in HR without bradycardia. The decrease in dosage of propofol with increasing doses of dexmedetomidine caused more stable MAP.
3. Dexmedetomidine is an ideal adjuvant drug to propofol during gastrointestinal endoscopy.