Among a total of 105,994 stroke patients registered from 2006 to 2016 in
the TSR, 15,031 were patients with intracerebral hemorrhage (Figure 1).
Patients with intracerebral hemorrhage caused by trauma or brain tumors
were not registered in this database. We excluded patients younger than
18 years old, and patients without information on dialysis status, body
mass index (BMI), systolic blood pressure levels, hemoglobin (Hb)
levels, serum cholesterol levels, or serum creatinine levels. Patients
who died during hospitalization were not excluded. A total of 4,036
hemorrhagic stroke patients were included in this study and divided into
five subgroups by the level of estimated glomerular filtration rate
(eGFR): ≥ 90 ml/min/1.73 m2, 60-89 ml/min/1.73
m2, 30-59 ml/min/1.73 m2, 15-29
ml/min/1.73 m2, and < 15 ml/min/1.73
m2 or on dialysis. The eGFR was calculated by the
Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for
each non-dialysis patient21. The CKD-EPI equation,
expressed as a single equation, is GFR = 141 × min (Scr/κ,
1)α × max (Scr/κ, 1)-1.209 ×
0.993Age × 1.018 [if female] × 1.159 [if
black], where Scr is serum creatinine, κ is 0.7 for females and 0.9
for males, α is -0.329 for females and -0.411 for males, min indicates
the minimum of Scr/κor 1, and max indicates the maximum of Scr/κ or 1.
The etiologies of intracerebral hemorrhage were classified into
hypertension and non-hypertensive causes. One-month and one-year
mortality rates after intracerebral hemorrhage were evaluated by the
eGFR levels.