Table 1. Baseline characteristics of patients with intracerebral hemorrhage at admission by eGFR levels at admission
eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2 eGFR mL/min/1.73 m2
Variable
Total N=4036 Total N=4036 Total N=4036 ≧90 N=1149 (28.5%) ≧90 N=1149 (28.5%) ≧90 N=1149 (28.5%) ≧90 N=1149 (28.5%) 60-89 N=1746 (43.3%) 60-89 N=1746 (43.3%) 60-89 N=1746 (43.3%) 60-89 N=1746 (43.3%) 30-59 N=837 (20.7%) 30-59 N=837 (20.7%) 30-59 N=837 (20.7%) 30-59 N=837 (20.7%) 15-29 N=135 (3.34%) 15-29 N=135 (3.34%) 15-29 N=135 (3.34%) 15-29 N=135 (3.34%) <15 or dialysis N=169(4.19%) <15 or dialysis N=169(4.19%) <15 or dialysis N=169(4.19%) <15 or dialysis N=169(4.19%)
p-value
Men, N (%) 2677 (66.3) 749 749 (65.2) (65.2) 1174 1174 (67.2) (67.2) 573 573 (68.5) (68.5) 82 82 (60.7) (60.7) 99 99 (58.6) (58.6) 0.05 0.05
Age, year, median (Q1, Q3) 61.4 (51.7,72.9) (51.7,72.9) 54.2 54.2 (46.1,61.4) (46.1,61.4) 63.3 63.3 (53.2,74.1) (53.2,74.1) 71.0 71.0 (58.7,80.2) (58.7,80.2) 70.0 70.0 (58.5,79.6) (58.5,79.6) 60.5 60.5 (52.6,69.2) (52.6,69.2) <0.0001
BMI, kg/m2, median (Q1, Q3) 24.4 (21.8,27.5) (21.8,27.5) 24.7 24.7 (22.1,27.6) (22.1,27.6) 24.4 24.4 (22.0,24.7) (22.0,24.7) 24.2 24.2 (21.5,27.1) (21.5,27.1) 24.0 24.0 (20.6,26.6) (20.6,26.6) 22.8 22.8 (20.1,25.8) (20.1,25.8) <0.0001
Smoking <0.0001
Current
1061
(26.3)
(26.3)
384
384
(33.4)
(33.4)
450
450
(25.8)
(25.8)
164
164
(19.6)
(19.6)
29
29
(21.5)
(21.5)
34
34
(20.1)
(20.1)
Past
408
(10.1)
(10.1)
92
92
(8.01)
(8.01)
185
185
(10.6)
(10.6)
105
105
(12.5)
(12.5)
13
13
(9.63)
(9.63)
13
13
(7.69)
(7.69)
Etiology
0.31
Hypertensive
3351
(83.0)
(83.0)
936
936
(81.5)
(81.5)
1458
1458
(83.5)
(83.5)
697
697
(83..3)
(83..3)
112
112
(83.0)
(83.0)
148
148
(87.6)
(87.6)
Non-hypertensive
685
(17.0)
(17.0)
213
213
(18.5)
(18.5)
288
288
(16.5)
(16.5)
140
140
(16.7)
(16.7)
23
23
(17.0)
(17.0)
21
21
(12.4)
(12.4)
Comorbidity, N (%)
Hypertension 3496 (86.6) (86.6) 943 943 (82.1) (82.1) 1517 1517 (86.9) (86.9) 757 757 (90.4) (90.4) 120 120 (88.9) (88.9) 159 159 (94.1) (94.1) <0.0001
AF 102 (2.53) (2.53) 18 18 (1.57) (1.57) 36 36 (2.06) (2.06) 32 32 (3.82) (3.82) 13 13 (9.63) (9.63) 3 3 (1.78) (1.78) <0.0001
Previous stroke history 739 (18.3) (18.3) 140 140 (12.2) (12.2) 333 333 (19.1) (19.1) 197 197 (23.5) (23.5) 38 38 (28.2) (28.2) 31 31 (18.3) (18.3) <0.0001
Ischemic heart disease 298 (7.38) (7.38) 47 47 (4.09) (4.09) 108 108 (6.19) (6.19) 99 99 (11.8) (11.8) 18 18 (13.3) (13.3) 26 26 (15.4) (15.4) <0.0001
Congestive heart failure 49 (1.21) (1.21) 7 7 (0.61) (0.61) 12 12 (0.69) (0.69) 15 15 (1.79) (1.79) 9 9 (6.67) (6.67) 6 6 (3.55) (3.55) <0.0001
Diabetes mellitus 1048 (26.0) (26.0) 259 259 (22.5) (22.5) 384 384 (22.0) (22.0) 254 254 (30.4) (30.4) 66 66 (48.9) (48.9) 85 85 (50.3) (50.3) <0.0001
Systolic blood pressure, mmHg
177.0
(153.0,203.0)
(153.0,203.0)
170.0
170.0
(148.0,196.0)
(148.0,196.0)
179.0
179.0
(155.0,202.0)
(155.0,202.0)
181.0
181.0
(157.0,211.0)
(157.0,211.0)
184.0
184.0
(153.0,210.0)
(153.0,210.0)
187.0
187.0
(160.0,215.0)
(160.0,215.0)
<0.0001
Laboratory data, median (Q1, Q3)
Cholesterol, mg/dl
150.0
(104.0,192.0)
(104.0,192.0)
156.0
156.0
(112.0,197.0)
(112.0,197.0)
148.0
148.0
(100.0,192.0)
(100.0,192.0)
146.0
146.0
(100.0,187.0)
(100.0,187.0)
145.0
145.0
(110.0,205.0)
(110.0,205.0)
150.0
150.0
(108.0,191.0)
(108.0,191.0)
0.37
Hb, g/dl
14.2
(12.7,15.4)
(12.7,15.4)
14.6
14.6
(13.3,15.6)
(13.3,15.6)
14.4
14.4
(13.2,15.5)
(13.2,15.5)
13.7
13.7
(12.3,15.2)
(12.3,15.2)
11.8
11.8
(10.4,13.3)
(10.4,13.3)
10.6
10.6
(9.30,11.6)
(9.30,11.6)
<0.0001
NIHSS score at admission, median (Q1, Q3)
8.00
(3.00,17.0)
(3.00,17.0)
8.00
8.00
(3.00,16.0)
(3.00,16.0)
8.00
8.00
(3.00,15.0)
(3.00,15.0)
9.00
9.00
(3.00,21.0)
(3.00,21.0)
12.0
12.0
(4.00,29.0)
(4.00,29.0)
11.0
11.0
(4.00,25.0)
(4.00,25.0)
<0.0001
Medicine use prior to admission, N (%)
Antiplatelet drugs 367 (9.09) (9.09) 63 63 (5.48) (5.48) 162 162 (9.28) (9.28) 103 103 (12.3) (12.3) 20 20 (14.8) (14.8) 19 19 (11.2) (11.2) <0.0001
Warfarin
81
(2.01)
(2.01)
11
11
(0.96)
(0.96)
31
31
(1.78)
(1.78)
27
27
(3.23)
(3.23)
9
9
(6.67)
(6.67)
3
3
(1.78)
(1.78)
0.004
Lipid lowering drug
204
(5.05)
(5.05)
42
42
(3.66)
(3.66)
78
78
(4.47)
(4.47)
52
52
(6.21)
(6.21)
18
18
(13.3)
(13.3)
14
14
(8.28)
(8.28)
<0.0001
Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale Chi-square test, and Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale