eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | eGFR mL/min/1.73 m2 | |
Variable
|
Total N=4036 | Total N=4036 | Total N=4036 | ≧90 N=1149 (28.5%) | ≧90 N=1149 (28.5%) | ≧90 N=1149 (28.5%) | ≧90 N=1149 (28.5%) | 60-89 N=1746 (43.3%) | 60-89 N=1746 (43.3%) | 60-89 N=1746 (43.3%) | 60-89 N=1746 (43.3%) | 30-59 N=837 (20.7%) | 30-59 N=837 (20.7%) | 30-59 N=837 (20.7%) | 30-59 N=837 (20.7%) | 15-29 N=135 (3.34%) | 15-29 N=135 (3.34%) | 15-29 N=135 (3.34%) | 15-29 N=135 (3.34%) | <15 or dialysis N=169(4.19%) | <15 or dialysis N=169(4.19%) | <15 or dialysis N=169(4.19%) | <15 or dialysis N=169(4.19%) |
p-value
|
Men, N (%) | 2677 | (66.3) | 749 | 749 | (65.2) | (65.2) | 1174 | 1174 | (67.2) | (67.2) | 573 | 573 | (68.5) | (68.5) | 82 | 82 | (60.7) | (60.7) | 99 | 99 | (58.6) | (58.6) | 0.05※ | 0.05※ |
Age, year, median (Q1, Q3) | 61.4 | (51.7,72.9) | (51.7,72.9) | 54.2 | 54.2 | (46.1,61.4) | (46.1,61.4) | 63.3 | 63.3 | (53.2,74.1) | (53.2,74.1) | 71.0 | 71.0 | (58.7,80.2) | (58.7,80.2) | 70.0 | 70.0 | (58.5,79.6) | (58.5,79.6) | 60.5 | 60.5 | (52.6,69.2) | (52.6,69.2) | <0.0001※ |
BMI, kg/m2, median (Q1, Q3) | 24.4 | (21.8,27.5) | (21.8,27.5) | 24.7 | 24.7 | (22.1,27.6) | (22.1,27.6) | 24.4 | 24.4 | (22.0,24.7) | (22.0,24.7) | 24.2 | 24.2 | (21.5,27.1) | (21.5,27.1) | 24.0 | 24.0 | (20.6,26.6) | (20.6,26.6) | 22.8 | 22.8 | (20.1,25.8) | (20.1,25.8) | <0.0001※ |
Smoking | <0.0001※ | |||||||||||||||||||||||
Current |
1061
|
(26.3)
|
(26.3)
|
384
|
384
|
(33.4)
|
(33.4)
|
450
|
450
|
(25.8)
|
(25.8)
|
164
|
164
|
(19.6)
|
(19.6)
|
29
|
29
|
(21.5)
|
(21.5)
|
34
|
34
|
(20.1)
|
(20.1)
|
|
Past |
408
|
(10.1)
|
(10.1)
|
92
|
92
|
(8.01)
|
(8.01)
|
185
|
185
|
(10.6)
|
(10.6)
|
105
|
105
|
(12.5)
|
(12.5)
|
13
|
13
|
(9.63)
|
(9.63)
|
13
|
13
|
(7.69)
|
(7.69)
|
|
Etiology |
0.31
|
|||||||||||||||||||||||
Hypertensive |
3351
|
(83.0)
|
(83.0)
|
936
|
936
|
(81.5)
|
(81.5)
|
1458
|
1458
|
(83.5)
|
(83.5)
|
697
|
697
|
(83..3)
|
(83..3)
|
112
|
112
|
(83.0)
|
(83.0)
|
148
|
148
|
(87.6)
|
(87.6)
|
|
Non-hypertensive |
685
|
(17.0)
|
(17.0)
|
213
|
213
|
(18.5)
|
(18.5)
|
288
|
288
|
(16.5)
|
(16.5)
|
140
|
140
|
(16.7)
|
(16.7)
|
23
|
23
|
(17.0)
|
(17.0)
|
21
|
21
|
(12.4)
|
(12.4)
|
|
Comorbidity, N (%) | ||||||||||||||||||||||||
Hypertension | 3496 | (86.6) | (86.6) | 943 | 943 | (82.1) | (82.1) | 1517 | 1517 | (86.9) | (86.9) | 757 | 757 | (90.4) | (90.4) | 120 | 120 | (88.9) | (88.9) | 159 | 159 | (94.1) | (94.1) | <0.0001 |
AF | 102 | (2.53) | (2.53) | 18 | 18 | (1.57) | (1.57) | 36 | 36 | (2.06) | (2.06) | 32 | 32 | (3.82) | (3.82) | 13 | 13 | (9.63) | (9.63) | 3 | 3 | (1.78) | (1.78) | <0.0001※ |
Previous stroke history | 739 | (18.3) | (18.3) | 140 | 140 | (12.2) | (12.2) | 333 | 333 | (19.1) | (19.1) | 197 | 197 | (23.5) | (23.5) | 38 | 38 | (28.2) | (28.2) | 31 | 31 | (18.3) | (18.3) | <0.0001※ |
Ischemic heart disease | 298 | (7.38) | (7.38) | 47 | 47 | (4.09) | (4.09) | 108 | 108 | (6.19) | (6.19) | 99 | 99 | (11.8) | (11.8) | 18 | 18 | (13.3) | (13.3) | 26 | 26 | (15.4) | (15.4) | <0.0001※ |
Congestive heart failure | 49 | (1.21) | (1.21) | 7 | 7 | (0.61) | (0.61) | 12 | 12 | (0.69) | (0.69) | 15 | 15 | (1.79) | (1.79) | 9 | 9 | (6.67) | (6.67) | 6 | 6 | (3.55) | (3.55) | <0.0001※ |
Diabetes mellitus | 1048 | (26.0) | (26.0) | 259 | 259 | (22.5) | (22.5) | 384 | 384 | (22.0) | (22.0) | 254 | 254 | (30.4) | (30.4) | 66 | 66 | (48.9) | (48.9) | 85 | 85 | (50.3) | (50.3) | <0.0001※ |
Systolic blood pressure, mmHg |
177.0
|
(153.0,203.0)
|
(153.0,203.0)
|
170.0
|
170.0
|
(148.0,196.0)
|
(148.0,196.0)
|
179.0
|
179.0
|
(155.0,202.0)
|
(155.0,202.0)
|
181.0
|
181.0
|
(157.0,211.0)
|
(157.0,211.0)
|
184.0
|
184.0
|
(153.0,210.0)
|
(153.0,210.0)
|
187.0
|
187.0
|
(160.0,215.0)
|
(160.0,215.0)
|
<0.0001#
|
Laboratory data, median (Q1, Q3) | ||||||||||||||||||||||||
Cholesterol, mg/dl |
150.0
|
(104.0,192.0)
|
(104.0,192.0)
|
156.0
|
156.0
|
(112.0,197.0)
|
(112.0,197.0)
|
148.0
|
148.0
|
(100.0,192.0)
|
(100.0,192.0)
|
146.0
|
146.0
|
(100.0,187.0)
|
(100.0,187.0)
|
145.0
|
145.0
|
(110.0,205.0)
|
(110.0,205.0)
|
150.0
|
150.0
|
(108.0,191.0)
|
(108.0,191.0)
|
0.37#
|
Hb, g/dl |
14.2
|
(12.7,15.4)
|
(12.7,15.4)
|
14.6
|
14.6
|
(13.3,15.6)
|
(13.3,15.6)
|
14.4
|
14.4
|
(13.2,15.5)
|
(13.2,15.5)
|
13.7
|
13.7
|
(12.3,15.2)
|
(12.3,15.2)
|
11.8
|
11.8
|
(10.4,13.3)
|
(10.4,13.3)
|
10.6
|
10.6
|
(9.30,11.6)
|
(9.30,11.6)
|
<0.0001#
|
NIHSS score at admission, median (Q1, Q3) |
8.00
|
(3.00,17.0)
|
(3.00,17.0)
|
8.00
|
8.00
|
(3.00,16.0)
|
(3.00,16.0)
|
8.00
|
8.00
|
(3.00,15.0)
|
(3.00,15.0)
|
9.00
|
9.00
|
(3.00,21.0)
|
(3.00,21.0)
|
12.0
|
12.0
|
(4.00,29.0)
|
(4.00,29.0)
|
11.0
|
11.0
|
(4.00,25.0)
|
(4.00,25.0)
|
<0.0001#
|
Medicine use prior to admission, N (%) | ||||||||||||||||||||||||
Antiplatelet drugs | 367 | (9.09) | (9.09) | 63 | 63 | (5.48) | (5.48) | 162 | 162 | (9.28) | (9.28) | 103 | 103 | (12.3) | (12.3) | 20 | 20 | (14.8) | (14.8) | 19 | 19 | (11.2) | (11.2) | <0.0001※ |
Warfarin |
81
|
(2.01)
|
(2.01)
|
11
|
11
|
(0.96)
|
(0.96)
|
31
|
31
|
(1.78)
|
(1.78)
|
27
|
27
|
(3.23)
|
(3.23)
|
9
|
9
|
(6.67)
|
(6.67)
|
3
|
3
|
(1.78)
|
(1.78)
|
0.004※
|
Lipid lowering drug |
204
|
(5.05)
|
(5.05)
|
42
|
42
|
(3.66)
|
(3.66)
|
78
|
78
|
(4.47)
|
(4.47)
|
52
|
52
|
(6.21)
|
(6.21)
|
18
|
18
|
(13.3)
|
(13.3)
|
14
|
14
|
(8.28)
|
(8.28)
|
<0.0001※
|
※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale | ※Chi-square test, and #Kruskal-Wallis test eGFR, estimated glomerular filtration rate; Q1, 25th percentile; Q3, 75th percentile; SD, standard deviation; BMI, body mass index; AF, atrial fibrillation; Hb, hemoglobin; NIHSS, National Institutes of Stroke Scale |