Introduction
Stroke is one of major causes of death and disability worldwide and it
has become the fourth leading cause of death in the
US.1 The impacts of stroke on quality of life,
productivity, and health care costs are tremendous. Because of the high
social and financial burden, it is important to study the prognostic
factors after stroke.
Renal dysfunction is one of the risk factors for the development of
cardiovascular disease, including stroke, and
death.2-5 On the other hand, renal function impairment
is highly prevalent in patients with stroke. Up to 50 % of stroke
patients have preexisting renal dysfunction.6,7Previous studies have shown that the renal dysfunction predicts the
risks of both mortality and new cardiovascular events in patient with
stroke.7-9 There is a graded relationship between
renal dysfunction and cardiovascular outcomes, including deaths in these
patients. In our previous studies, we also found that the estimated
glomerular filtration rate (eGFR) is associated with risks of both
1-month and 1-year mortality and of recurrence in patients with acute
ischemic stroke.10,11 Intracerebral hemorrhage is a
more devastating stroke than ischemic stroke, carrying a higher risk of
subsequent morbidity and mortality.12,13 Renal
dysfunction has been found to be a poor prognostic factor in patients
with intracerebral hemorrhage.14-18 However, other
studies failed to show renal dysfunction as a significant predictor of
mortality in patients with intracerebral
hemorrhage.8,19 Because of previous inconsistent
results, this study investigated whether the risks of 1-month and 1-year
mortality are associated with eGFR levels in patients with intracerebral
hemorrhage using the Taiwan Stroke Registry (TSR) database.