*: frequency per year of hospitalization in a hospital Emergency Department (ED) for severe asthmatic exacerbation, calculated since two years of age

#: an obstructive defect is defined by a z-score of FEV₁/FVC < -1.645.

BMI denotes body mass index, SABA denotes short-acting beta agonist treatment, ICS denotes inhaled corticosteroid, BED denotes beclomethasone-equivalent daily dose, LABA denotes long-acting beta agonist

^$: severe exacerbation is defined according to Reddel et al.²⁶

^§: Severe asthma defined by FEV₁< 80% predicted and a z-score of FEV₁/FVC < -1.645, according to international recommendations²³