Background:
Sepsis is the most common health problem because of which an increased
proportion of health resources are consumed. Tumour Necrosis factor
alpha also plays an essential role in many diseased conditions like
diabetes, cancer, etc. There have been findings suggesting a high level
of correlation between TNF activity and sepsis susceptibility and
mortality. Thus, the present meta-analysis was carried out to assess the
role of Tumour Necrosis Factor-Alpha promoter 308A/G polymorphism in
sepsis and sepsis mortality.
Methods: The meta-analysis was carried out using the MOOSE
guidelines. A total number of 782 articles were retrieved, out of which
only 45 full-text articles were eligible. Out of that, 24 were used for
meta-analysis after checking the quality of articles. The meta-analysis
was carried out using MedCalc Software. The comparison of TNF factor
alpha 1 and 2 among patients was calculated in the two groups. The odds
ratio of these studies was used to construct the forest plot.
Results: Eight studies evaluated the odds of having increased
TNF1 in sepsis conditions. The plot shows that the cumulative statistics
are significant at a 95% confidence level and have a p-value less than
0.05. The odds of increased TNF2 in sepsis conditions among Asians are
more than in the case of TNF1. The odds ratio of 0.978 indicates that
the odds of increased TNF1 in sepsis conditions among Caucasians are
more than in the case of TNF2.
Conclusion: The meta-analysis suggests an association between
the G/A allele combination of TNF-α and sepsis risk in the Asian
population compared to the Caucasian Population.
Keywords: Tumor Necrosis Factor (TNF); 308 A/G Polymorphism; Sepsis;
Sepsis Mortality; Asians; Caucasians.
What is already known about this topic?
Tumour Necrosis factor alpha plays a vital role in many body’s diseased
conditions like diabetes, cancer, etc. The studies conducted in the past
have produced mixed results on the role of TNF-\(\propto\) during
weakened health conditions. Very few studies determined its role in
sepsis and its associated mortality. However, few studies demonstrate
that it has no role in the Caucasians.
What does this article add?
This is an updated meta-analysis of all the studies done so far on the
TNF-α and its relationship with the sepsis and sepsis mortality
especially, in the Asian population when compared to the Caucasians.