Introduction
Sepsis is defined as the infection that causes the immune system to attack the body, subsequently leading to an individual’s death. Sepsis is the most common health problem because of which an increased proportion of health resources are consumed. It is most commonly seen in the elderly, preterm infants, or low birth weight infants.1,2 Various studies in the past have shown an association between the polymorphism and sepsis-related mortality.3 Several biomarkers have been seen to show an elevated level in sepsis condition like TLR4 (toll-like receptor 4) single nucleotide polymorphisms, rs4986790, and rs4986791, but not the SERPINE1 [Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1] rs1799768 polymorphism.4-8
Tumour Necrosis factor alpha also plays a vital role in many body’s diseased conditions like diabetes, cancer, etc. The studies conducted in the past have produced mixed results on the role of TNF-\(\propto\)during weakened health conditions. One study reported this as a risk factor in the North Indian population, Japanese patients, Chinese, Turkish children. Studies in Germany and Hungary revealed a negative correlation between preterm infants and low birth weight infants.8-19
However, there are several genomic variants of the TNF factor-\(\propto\)of which the biallelic polymorphism at position 308 is associated with sepsis.20,21 There have been findings suggesting a high level of correlation between TNF activity and sepsis susceptibility and mortality. 22-23. However, there is an equal number of evidence contradicting the findings.24 Thus, the present meta-analysis is carried out to assess the role of Tumour Necrosis Factor-Alpha promoter 308A/G polymorphism in sepsis and sepsis mortality.