3. Results:
Baseline characteristics of the study participants are shown inTable 1 . Out of these 97 recruited patients, 38 had CAD based on the criteria defined in methods. CAD patients more often had significant CAC (≥100 score) as compared to non-CAD patients (29% vs 1.7%, p value: 0.001). QRISK3 score was significantly more in CAD vs non-CAD patients (17.8% vs 12.4%, p value: 0.007).
EAT-T measured by echocardiography, as well as EAT-V measured by CTA was significantly more in CAD patients as compared to non-CAD patients (Table 2 ). EAT-V measured by CTA showed significant correlation with EAT-T measured by echocardiography, both absolute and indexed, as shown in Table 3 and Table4 .
On receiver operating characteristic (ROC) curve analysis, EAT-T (PLAX) ≥3.9 mm (AUC 0.68; 95% CI 0.58-0.79, sensitivity of 84% and specificity of 55%), EAT-T (PSAX ) ≥3.8 mm (AUC 0.66; 95% CI 0.56-0.78, sensitivity of 84% and specificity of 50%), indexed EAT-T (PLAX) ≥2.2 mm/ m2 (AUC 0.69; 95% CI 0.59-0.80, sensitivity of 85% and specificity of 50%), and indexed EAT-T (PSAX ) ≥2.1 mm/ m2 (AUC 0.67; 95% CI 0.57-0.78, sensitivity of 89% and specificity of 44%) predicted the presence of CAD (Figure 3 ). Similarly, EAT-V ≥101 cm3(AUC 0.73; 95% CI 0.64-0.84, sensitivity of 92% and specificity of 51%) and indexed EAT-V ≥60 cm3/ m2(AUC 0.76; 95% CI 0.68-0.86, sensitivity of 92% and specificity of 59%) predicted the presence of CAD (Figure 3 ).
On univariate regression analysis EAT-T by PLAX (absolute value ≥3.9 mm and indexed value ≥ 2.2 mm/m2) and by PSAX (absolute value ≥3.8 mm and indexed value ≥2.1 mm/m2) showed significant association with CAD with odds ratios for CAD as shown inTable 5 .
Multivariate regression analysis with QRISK3 score revealed that EAT-T by PLAX and PSAX (both absolute as well as indexed value) showed significant association with CAD (Table 6 ). The odds ratio of having CAD at EAT-T (PLAX) ≥3.9 mm and EAT-T (PSAX) ≥3.8 mm was 2.8 (95% CI 1.15-6.75, p=0.02) and 2.6 (95% CI 1.07-6.03, p=0.03) respectively. Similarly, the odds ratio of indexed EAT-T (PLAX) ≥2.2 mm/m2 and indexed EAT-T (PSAX) ≥2.1 mm/m2 was 5.4 (95% CI 2.17-13.55, p<0.001) and 3.3 (95% CI 1.37-7.93, p=0.01) respectively.