2.2 The synthesis of NF-κB inhibitors
The classic synthesis method of chalcone derivatives is to condense
substituted acetophenone and substituted benzaldehyde in alkaline
alcohol solution. Because the phenolic hydroxyl group is easy to be
oxidized, especially under alkaline conditions. The reaction yield of
hydroxychalcone is very low in the classical synthesis of
hydroxychalcone. So we explored a method of preparing hydroxychalcone by
direct condensation reaction under the catalysis of thionyl chloride.
Using thionyl chloride as a catalyst and ethanol as a solvent,
hydroxyacetophenone and hydroxybenzaldehyde are condensed at room
temperature for 24 hours to obtain various hydroxychalcone derivatives.
The detail information is showed in the supplementary information.