Interventions
Out of 350 trials, 104 (29.7%) assessed treatments primarily on PTB
prevention (e.g. progesterone in n=45 trials (43.3%), cervical cerclage
in n=14 (13.5%), periodontal interventions in n=14 (13.5%), uterine
home-monitoring in n=9 (8.7%) and smaller groups of trials on bed-rest,
pessary, antibiotic and antihypertensive use (Table S3). A total of 246
trials (70.3%) stated PTB as one of their secondary aims (e.g.
nutritional supplements/multi micronutrients/minerals in n=103 trials
(41.9%), aspirin n=24 (9.8%), lifestyle (n=15) and behavioural
interventions (n=15) (Table S3). The most common comparators were usual
care n=151 (43.1%) or placebo n=146 (41.7%).