Infectious complications and SSR
No differences in CRP levels according to the presence of VO were
observed in patients with infectious complications (Figure 2b).
Univariate analysis in this subgroup of patients did not reveal any
association with abnormal CRP values in the post-operative period, so
that multivariate analysis was unnecessary (Supplementary Table 1).
Further analysis was therefore conducted only for patients without
infectious complications. In this subgroup, CRP values were
significantly higher in VO compared to non-VO patients on POD1, POD2,
POD3 and POD5 (Figure 2a). Univariate analysis showed a positive
correlation between CRP from POD 1 to 3, and VO (Supplementary Table 2),
with the highest coefficient on POD2 (β=0.200; p=0.001). In multivariate
analysis (Table 5), VO was confirmed as independent risk factor for
increased CRP values between POD1-3. Other factors associated with high
CRP values were conversion to open surgery (POD1-2) and time of surgery
(POD 1-4). ERAS enrollment was independently associated with lower CRP
values on POD2, POD3 and POD5.